Glyoxalase II: molecular characteristics, kinetics and mechanism.
نویسنده
چکیده
The mechanism that has been proposed for glyoxalase II [36] is summarized in Figure 3. It involves direct nucleophilic attack of an active-site histidine on the thiol ester substrate to form an acyl-imidazole intermediate which then rapidly hydrolyses. This is consistent with the known susceptibility of thiol esters to aminolysis and with the lability of acyl-imidazoles [47].
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 21 2 شماره
صفحات -
تاریخ انتشار 1993